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Metabolic-targeted therapies, including pathway modulators, enzyme inhibitors, and metabolic agents, represent a novel therapeutic frontier

The three modifications included: amino acid substitution at position 8 changing alanine to alpha-aminoisobutyric acid, and position 34, changing lysine to arginine, as well as acylation of the lysine in position 26 with a spacer and a C-18 fatty acid chain

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